MDDC were also infected with DENV and then the supernatant was analyzed by the Bio-Plex human cytokine 27-plex immunoassay for the production of IFN-¦Ã, IFN-¦Á, RANTES, MIP-1¦Á, MIP-1¦Â and TNF-¦Á, which all have been demonstrated to play a role in the DENV pathogenesis. We observed an enhanced production of all these cytokines/chemokines in the supernatant analyzed 48 h after DENV infection. Addition of 10 ¦Ìg/ml of HHA or GNA profoundly inhibited the induction of RANTES, MIP-1¦Á, MIP-1¦Â, IFN-¦Á and TNF-¦Á, and to a lesser extent the production of IFN-¦Ã. The cytokines/chemokines production was also evaluated in uninfected MDDC incubated with CBAs. These agents, by themselves, had no effect on the cytokine/chemokine production profile compared to the uninfected MDDC. Thus, we demonstrated that the CBAs, in addition to their consistent antiviral activity, inhibited the secretion of several pro-inflammatory cytokines and chemokines important in the DENV pathogenesis, rendering CBAs as attractive protein lead structures to combat DENV transmission and infection.