- 作者：Eun-Sik Jang ; Jun-Woo Park ; HaeYong Kweon ; Kwang-Gill Lee ; Seok-Woo Kang ; Dong-Heon Baek ; Je-Yong Choi ; Seong-Gon Kim
- 刊名：Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology
- 出版年：2010
- 出版时间：June 2010
- 年：2010
- 卷：109
- 期：6
- 页码：831-836
- 全文大小：649 K
Objective
The objective of this study was to determine the capability of silk fibroin powder as a biomaterial template for the restoration of peri-implant defects when mixed with Choukroun platelet-rich fibrin (PRF) in vivo.Study design
Ten New Zealand white rabbits were used for this study. Using a trephine bur (diameter 7.0 mm), 2 monocortical defects were prepared. Subsequently, 2 dental implants were installed into the tibia (diameter 3.0 mm, length 10.0 mm). In the experimental group, the peri-implant defect was filled with a combination graft of silk fibroin powder and Choukroun PRF. The control was left in an unfilled state. The animals were killed at 8 weeks. Subsequently, a removal torque test and a histomorphometric analysis were done.
Results
The removal torque for the experimental group was 30.34 ± 5.06 N·cm, whereas it was 21.86 ± 3.39 N·cm for the control. The difference between the 2 groups was statistically significant (P = .010). Mean new bone formation was 51.93 ± 27.90 % in the experimental group and 11.67 ± 15.12 % in the control (P = .003). Mean bone-to-implant contact was 43.07 ± 21.96 % in the experimental group and 15.37 ± 23.84 % in the control (P = .002).
Conclusion
A peri-implant defect can be successfully repaired by the application of Choukroun PRF and silk fibroin powder.