Diagnosis and Whole Body Screening Using Blood Pool Scintigraphy for Evaluating Congenital Vascular Malformations

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• 作者：Young Hwan Kim¹ ; ² ; Joon Young Choi² ; ^{jynm.choi@samsung.com" class="auth_mail} ; Young-Wook Kim³ ; Dong-Ik Kim³ ; Young Soo Do⁴ ; Yearn Seong Choe² ; Kyung-Han Lee² ; Byung-Tae Kim²
• 刊名：Annals of Vascular Surgery
• 出版年：April, 2014
• 年：2014
• 卷：28
• 期：3
• 页码：673-678
• 全文大小：852 K

文摘

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Background

Because magnetic resonance imaging and angiography are inappropriate for whole-body screening because of high cost or invasiveness, we investigated the potential of whole-body blood pool scintigraphy (WBBPS) as a screening and diagnostic tool for congenital vascular malformations (CVMs).

Methods

The subjects of the study were 137 patients (mean age: 20聽卤聽16聽years; range: 0.3-68聽years) with suspected CVM. Whole-body anterior and posterior images were acquired twenty minutes after injection of 760 MBq ^99mTc-labeled red blood cells (pediatric dose: 13聽MBq/kg). The final diagnosis was determined by clinical findings, magnetic resonance imaging, angiography, Doppler sonography, and lymphoscintigraphy.

Results

Of these patients, 124 had venous malformations, and 13 had lymphatic malformations. WBBPS successfully detected abnormal blood pooling lesions in 96.8% (120/124) of the patients with venous malformations. None of the patients with lymphatic malformation showed abnormal uptake on WBBPS. In addition, WBBPS detected 41 additional abnormal vascular lesions that were not found during initial clinical evaluation in 16.9% (21/124) of the patients with venous malformations.

Conclusion

WBBPS is a valuable diagnostic and screening modality for the initial evaluation of CVM because of its high characterizing accuracy of 97.1% and the ability to image the whole body.