Design and synthesis of formononetin-dithiocarbamate hybrids that inhibit growth and migration of PC-3 cells via MAPK/Wnt signaling pathways

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• 作者：Dong-Jun Fu^a ; ¹ ; Li Zhang^a ; ¹ ; Jian Song^a ; ¹ ; Ruo-Wang Mao^a ; Ruo-Han Zhao^a ; Ying-Chao Liu^a ; Yu-Hui Hou^a ; Jia-Huan Li^a ; Jia-Jia Yang^a ; Cheng-Yun Jin^a ; Ping Li^a ; Xiao-Lin Zi^c ; Hong-Min Liu^a ; Sai-Yang Zhang^b ; ^{celeron16@163.com} ; Yan-Bing Zhang^a ; ^{zhangyb@zzu.edu.cn}
• 关键词：Formononetin ; Dithiocarbamate ; Growth ; Migration
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：127
• 期：Complete
• 页码：87-99
• 全文大小：3500 K
• 卷排序：127

文摘

A series of ormononetin-dithiocarbamate hybrids were discovered as novel antiproliferative inhibitors. Structure-activity relationship for formononetin-dithiocarbamate scaffold. Compound 8i inhibit growth and migration of PC-3 cells via MAPK/Wnt signaling pathways.