Genotypic and antigenic characterization of hemagglutinin proteins of African measles virus isolates

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• 作者：Truong ; Anh T. ; Kreis ; Stephanie ; Ammerlaan ; Wim ; Hartter ; Heike K. ; Adu ; Festus ; et. al.
• 关键词：Measles virus ; Hemagglutinin ; Sequence ; Africa ; Monoclonal antibodies
• 刊名：Virus Research
• 出版年：1999
• 出版时间：July, 1999
• 年：1999
• 卷：62
• 期：1
• 页码：89-95
• 全文大小：148 K

文摘

A comprehensive phylogenetic study based on the hemagglutinin (H) protein of all known African measles virus (MV) isolates is presented. The study includes 64 new H gene sequences from Ghana, Nigeria and South Africa as well as viruses from Zambia and The Gambia for which only incomplete sequencing data were available and that have previously not been genotyped. The results provide further support to the tentative assignment of the Nigerian and Ghanaian viruses to a new genotype B3 within clade B. A distinct geographic distribution pattern emerged with clade B viruses circulating exclusively in African countries north of the equator. All MV strains from southern Africa grouped in clades A and D with the majority of viruses belonging to genotype D4. The viruses considerably differed by their sensitivity to neutralization by monoclonal antibodies (mAb), but three selected antibodies were sufficient to distinguish between African MVs representing four different genotypes. Publisher: Elsevier Science Language of Publication: English Item Identifier: S0168-1702(99)00072-6 Publication Type: Miscellaneous ISSN: 0168-1702 Cited by:

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Footnotes:

1. Present address: Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30033, USA.

2. The sequences described in this paper have been deposited in GenBank under accession numbers AY026867-AY026894.