Klf2 and Tfcp2l1, Two Wnt/尾-Catenin Targets, Act Synergistically to Induce and Maintain Naive Pluripotency
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- 作者：Dongbo Qiu1 ; 2 ; 4 ; Shoudong Ye2 ; 3 ; 4 ; Bryan Ruiz2 ; Xingliang Zhou2 ; Dahai Liu3 ; Qi Zhang1 ; Qi-Long Ying2 ; qying@med.usc.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Stem Cell Reports
- 出版年：2015
- 出版时间：8 September 2015
- 年：2015
- 卷：5
- 期：3
- 页码：314-322
- 全文大小：2007 K
文摘
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Klf2 and Tfcp2l1 are downstream targets of Wnt/尾-catenin
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Klf2 and Tfcp2l1 overexpression maintains mESC self-renewal
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Downregulation of Klf2 and Tfcp2l1 impairs mESC self-renewal mediated by 2i
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KLF2 and TFCP2L1 promote reprogramming of EpiSCs to naive ESCs