A Fluorescent Reporter Mouse for Inflammasome Assembly Demonstrates an Important Role for Cell-Bound and Free ASC Specks during In Vivo Infection
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- 作者：Te-Chen Tzeng1 ; Stefan Schattgen1 ; 3 ; Brian Monks1 ; 2 ; Donghai Wang1 ; 4 ; Anna Cerny1 ; Eicke Latz1 ; 2 ; Katherine Fitzgerald1 ; Douglas T. Golenbock1 ; douglas.golenbock@umassmed.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：12 July 2016
- 年：2016
- 卷：16
- 期：2
- 页码：571-582
- 全文大小：3281 K
文摘
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The ASC-citrine mouse is a transgenic model that reports inflammasome activation
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ASC-citrine retains the function of endogenous ASC
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Non-hematopoietic cells are capable of forming ASC specks on activation
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The ASC-citrine mouse recapitulates the formation of free specks in vivo