Cholesterol efflux capacity is an independent predictor of all-cause and cardiovascular mortality in patients with coronary artery disease: A prospective cohort study
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- 作者：Chaoqun Liua ; Yuan Zhangb ; Ding Dinga ; Xinrui Lia ; Yunou Yanga ; Qing Lia ; Yuanzhu Zhenga ; Dongliang Wanga ; wdliang@mail.sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Wenhua Linga ; lingwh@mail.sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：High-density lipoprotein ; Cholesterol efflux capacity ; Coronary artery disease ; All-cause mortality ; Cardiovascular mortality
- 刊名：Atherosclerosis
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：249
- 期：Complete
- 页码：116-124
- 全文大小：1007 K
文摘
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Cholesterol efflux capacity was inversely associated with risk of all-cause and cardiovascular mortality in both ACS and stable CAD patients, independent of circulating HDL cholesterol level.
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Adding cholesterol efflux capacity to a model containing traditional cardiovascular risk factors significantly increased its discriminatory power and predictive ability for all-cause and cardiovascular mortality.
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Furthermore, our findings reveal that an increase in circulating HDL-C levels does not enhance cholesterol efflux capacity when its level is over 50 mg/dL in patients with CAD.