A potential food biopreservative, CecXJ-37N, non-covalently intercalates into the nucleotides of bacterial genomic DNA beyond membrane attack
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- 作者：Dongliang Liua ; 1 ; Jun Liua ; 1 ; Jinyao Lia ; Lijie Xiaa ; Jianhua Yanga ; b ; Surong Suna ; Ji Maa ; Fuchun Zhanga ; zfcxju@qq.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Antimicrobial peptide ; Food preservative ; Food-borne pathogen ; Amide modification ; Cell membrane penetration ; DNA intercalation
- 刊名：Food Chemistry
- 出版年：2017
- 出版时间：15 February 2017
- 年：2017
- 卷：217
- 期：Complete
- 页码：576-584
- 全文大小：1726 K
文摘
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CecXJ-37N shows small MICs (0.25–7.8 μM) against 8 food-borne pathogenic strains.
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CecXJ-37N shows low hemolysis and no cytotoxicity to normal mammalian cells.
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CecXJ-37N induces pore-forming on E. coli cell membrane and causes cytolysis.
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CecXJ-37N penetrates bacterial cell membrane and interacts with genomic DNA.
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CecXJ-37N intercalates into nucleotides rather than binds to DNA backbone.