Initiation & completion rates of hepatitis A vaccination among US pediatric populations born between 2005 and 2009

详细信息    查看全文

• 作者：Thomas Weiss^a ; ^{Thomas_weiss@merck.com" class="auth_mail" title="E-mail the corresponding author} ; Dongmu Zhang^a ; Nagesh N. Borse^b ; Emmanuel B. Walter^c
• 关键词：Hepatitis A ; Vaccination ; US ; Initiation ; Completion ; Rates ; Pediatric ; Observational study ; Healthcare claims databases
• 刊名：Vaccine
• 出版年：2015
• 出版时间：27 November 2015
• 年：2015
• 卷：33
• 期：48
• 页码：6871-6877
• 全文大小：444 K

文摘

To estimate hepatitis A vaccine series initiation and completion rates, assess time to vaccination, identify missed opportunities for the hepatitis A vaccine series, and examine factors associated with hepatitis A vaccine series initiation and completion.

Methods

We conducted a retrospective, observational study using three healthcare claims databases separately. The study population was comprised of children born between years 2005 and 2009 that were continuously enrolled for at least three and a half years from the date of birth. Every child was followed from date of birth for three and a half years for hepatitis A vaccination.

Results

There were 93,735 eligible children from Clinformatics Data Mart, 202,513 from MarketScan Commercial, and 207,545 from MarketScan Medicaid. The overall hepatitis A vaccine series initiation rate was 63.8–79.4% and completion rate was 45.1–66.8% across the three databases. About 62.8–90.1% of the children who never initiated hepatitis A vaccine had at least one well visit from 1 year to three and a half years old. Children were more likely to initiate and complete the hepatitis A vaccine series if they were from more recent birth cohorts, from states with a hepatitis A vaccination recommendation prior to the ACIP universal recommendation, from states with daycare/school entry requirements, were enrolled in an HMO health plan, had pediatricians as primary providers, had more doctor's office/well visits and received MMR/Varicella vaccines.

Conclusion

In this study, approximately one in every three to five children remained unvaccinated against hepatitis A. Although the hepatitis A vaccine series initiation and completion improved from 2005 to 2009, vaccine coverage has stabilized in recent years. It is important for providers to identify every opportunity for hepatitis A vaccination and to assure that children get protection from this vaccine-preventable disease.