A new type of glucose biosensor based on surface acoustic wave resonator using Mn-doped ZnO multilayer structure
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- 作者：Jingting Luo ; Pingxiang Luo ; Min Xie ; Ke Du ; Bixia Zhao ; Feng Pan ; Ping Fan ; Fei Zeng ; Dongping Zhang ; Zhuanghao Zheng ; Guangxing Liang
- 关键词：Glucose ; Surface acoustic wave (SAW) ; ZnO ; Glucose oxidase functional immobilization ; Biosensor
- 刊名：Biosensors and Bioelectronics
- 出版年：2013
- 出版时间：15 November, 2013
- 年：2013
- 卷：49
- 期：Complete
- 页码：512-518
- 全文大小：1877 K
文摘
This work reports a high-performance Mn-doped ZnO multilayer structure Love mode surface acoustic wave (SAW) biosensor for the detection of blood sugar. The biosensor was functionalized via immobilizing glucose oxidase onto a pH-sensitive polymer which was attached on Mn-doped ZnO biosensor. The fabricated SAW glucose biosensor is highly sensitive, accurate and fast with good anti-interference. The sensitivity of the SAW glucose biosensor is 7.184 MHz/mM and the accuracy is 6.96¡Á10?3 mM, which is sensitive and accurate enough for glucose monitoring. A good degree of reversibility and stability of the glucose sensor is also demonstrated, which keeps a constant differential frequency shift up to 32 days. Concerning the time response to human serum, the glucose sensor shows a value of 4.6¡À0.4 min when increasing glucose concentrations and 7.1¡À0.6 min when decreasing, which is less than 10 min and reach the fast response requirement for medical applications. The Mn-doped ZnO Love mode SAW biosensor can be fully integrated with CMOS Si chips and developed as a portable, passive and wireless real time detection system for blood sugar monitoring in human serum.