Human papillomavirus oncoprotein E6 upregulates c-Met through p53 downregulation
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- 作者：Guoqing Qiana ; Dongsheng Wanga ; Kelly R. Maglioccab ; Zhongliang Hua ; c ; Sreenivas Nannapanenia ; Sungjin Kimd ; Zhengjia Chene ; Shi-Yong Suna ; Dong M. Shina ; Nabil F. Sabaa ; nfsaba@emory.edu" class="auth_mail" title="E-mail the corresponding author ; Zhuo G. Chena ; gzchen@emory.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Human papillomavirus ; c-Met ; p53 ; Head and neck cancer
- 刊名：European Journal of Cancer
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：65
- 期：Complete
- 页码：21-32
- 全文大小：1792 K
文摘
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Reducing human papillomavirus (HPV) oncogene E6 decreased both mRNA and protein expressions of c-Met.
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The upregulation of c-Met by HPV E6 is mediated by p53.
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High c-Met protein levels correlated with HPV positivity in oropharyngeal squamous cell carcinoma specimens.
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High c-Met protein levels correlated with worse disease-free survival in HPV-positive oropharyngeal squamous cell carcinoma patients.