Discovery of non-peptide small molecular CXCR4 antagonists as anti-HIV agents: Recent advances and future opportunities
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- 作者：Heng Zhang ; Dongwei Kang ; Boshi Huang ; Na Liu ; Fabao Zhao ; Peng Zhan ; zhanpeng1982@sdu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Xinyong Liu ; xinyongl@sdu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：AIDS ; HIV-1 ; CXCR4 ; Small molecular ; Entry inhibitors ; Drug design
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：23 May 2016
- 年：2016
- 卷：114
- 期：Complete
- 页码：65-78
- 全文大小：1902 K
文摘
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We reviewed recent advances on small molecular CXCR4 antagonists.
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We focused on the evolution of CXCR4 and structure-activity relationships of representative CXCR4 antagonists.
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We introduced the medicinal chemistry strategies and novel methodologies.