Wnt signaling during cochlear development

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• 作者：Vidhya Munnamalai ^{vmunnama@purdue.edu} ; Donna M. Fekete ; ^{dfekete@purdue.edu}
• 关键词：Wnt ; PCP ; Cochlea ; ¦Â-Catenin ; Hair cell ; Retina
• 刊名：Seminars in Cell and Developmental Biology
• 出版年：2013
• 出版时间：May, 2013
• 年：2013
• 卷：24
• 期：5
• 页码：480-489
• 全文大小：1522 K

文摘

Wnt signaling is a hallmark of all embryonic development with multiple roles at multiple developmental time points. Wnt signaling is also important in the development of several organs, one of which is the inner ear, where it participates in otic specification, the formation of vestibular structures, and the development of the cochlea. In particular, we focus on Wnt signaling in the auditory organ, the cochlea. Attempting to dissect the multiple Wnt signaling pathways in the mammalian cochlea is a challenging task due to limited expression data, particularly at proliferating stages. To offer predictions about Wnt activity, we compare cochlear development with that of other biological systems such as Xenopus retina, brain, cancer cells and osteoblasts. Wnts are likely to regulate development through crosstalk with other signaling pathways, particularly Notch and FGF, leading to changes in the expression of Sox2 and proneural (pro-hair cell) genes. In this review we have consolidated the known signaling pathways in the cochlea with known developmental roles of Wnts from other systems to generate a potential timeline of cochlear development.