Transcriptomic Characterization of SF3B1 Mutation Reveals Its Pleiotropic Effects in Chronic Lymphocytic Leukemia
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- 作者：Lili Wang1 ; 11 ; 15 ; Angela N. Brooks1 ; 2 ; 3 ; 15 ; Jean Fan4 ; 15 ; Youzhong Wan1 ; 13 ; 15 ; Rutendo Gambe1 ; Shuqiang Li7 ; Sarah Hergert1 ; Shanye Yin12 ; Samuel S. Freeman2 ; Joshua Z. Levin2 ; Lin Fan2 ; Michael Seiler14 ; Silvia Buonamici14 ; Peter G. Smith14 ; Kevin F. Chau11 ; Carrie L. Cibulskis2 ; Wandi Zhang1 ; Laura Z. Rassenti6 ; Emanuela M. Ghia6 ; Thomas J. Kipps6 ; Stacey Fernandes1 ; Donald B. Bloch10 ; Dylan Kotliar11 ; Dan A. Landau1 ; 11 ; Sachet A. Shukla1 ; Jon C. Aster8 ; Robin Reed12 ; David S. DeLuca2 ; Jennifer R. Brown1 ; 9 ; Donna Neuberg5 ; Gad Getz2 ; Kenneth J. Livak7 ; Matthew M. Meyerson1 ; Peter V. Kharchenko4 ; Catherine J. Wu1 ; 2 ; 9 ; 11 ; 16 ; cwu@partners.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：CLL ; SF3B1 ; Notch signaling ; RNA sequencing ; alternative splicing
- 刊名：Cancer Cell
- 出版年：2016
- 出版时间：14 November 2016
- 年：2016
- 卷：30
- 期：5
- 页码：750-763
- 全文大小：4966 K
文摘
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SF3B1 mutation causes alternative splicing in cell lines and primary CLL cells
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SF3B1 mutation-associated splice variants are enriched for 3′ splice sites
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SF3B1 mutation induces RNA changes affecting multiple CLL-associated pathways
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SF3B1 mutation modulates Notch signaling through an RNA splice variant of DVL2