mGlu5 receptor antagonist blocks bromocriptine-induced conditioned place preference in bilateral mesolimbic-lesioned rat
详细信息 查看全文
- 作者：Omar Ouachikha ; Carine Chassaina ; b ; Guilhem Pagè ; sc ; Franck Durifa ; b ; Aziz Hafidia ; azhafidi@univ-bpclermont.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Conditioned place preference ; 6-OHDA ; Parkinson ; Reward
- 刊名：Behavioural Brain Research
- 出版年：2017
- 出版时间：15 January 2017
- 年：2017
- 卷：317
- 期：Complete
- 页码：301-310
- 全文大小：2356 K
文摘
- •
Dopamine replacement therapy induces dopamine dysregulation syndrome in PD patients by sensitizing the pVTA-NAc pathway.
- •
Dopamine receptor agonist bromocriptine induces a positive reinforcement in bilateral pVTA-lesioned rats.
- •
This reinforcement is due to the activation of mGluR5. This receptor and glutamate are over expressed in the NAc shell of pVTA-lesioned rats.
- •
20">Antagonizing mGluR5 blocked the conditioned place preference expression and acquisition in pVTA-lesioned rats.
- •
25">Bromocriptine-induced reinforcement is due to the activation of the mGluR5 pathway in the NAc of pVTA-lesioned rats.