Corticotropin-releasing hormone and dopamine release in healthy individuals

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• 作者：Doris Payer^a ; ^b ; ^c ; Belinda Williams^a ; Esmaeil Mansouri^a ; Suzanna Stevanovski^a ; Shinichiro Nakajima^a ; Bernard Le Foll^a ; ^c ; ^d ; Stephen Kish^a ; ^c ; ^d ; Sylvain Houle^a ; ^c ; Romina Mizrahi^a ; ^c ; Susan R. George^d ; Tony P. George^c ; ^e ; Isabelle Boileau^a ; ^c ; ^{Isabelle.Boileau@camh.ca}
• 关键词：Corticotropin-releasing hormone (CRH) ; Dopamine (DA) ; Positron emission tomography (PET) ; [11C]-(+)-PHNO ; Stress-induced relapse ; Addiction
• 刊名：Psychoneuroendocrinology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：76
• 期：Complete
• 页码：192-196
• 全文大小：702 K
• 卷排序：76

文摘

We investigated dopamine release in striatum, midbrain and pallidum after injection of human corticotropin hormone (i.v.) in humans. Two positron emission tomography scans with the dopamine D2/3 receptor agonist [11C]-(+)-PHNO were conducted: one after placebo and one after iv corticotropin hormone. We report that iv corticotropin hormone led to a detectable decrease in overall [11C]-(+)-PHNO binding, interpreted as increased dopamine release.