Exploring personality traits related to dopamine D_2/3 receptor availability in striatal subregions of humans

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• 作者：Fernando Caravaggio^a ; ^b ; Gagan Fervaha^a ; ^b ; Jun Ku Chung^a ; ^b ; Philip Gerretsen^a ; ^b ; ^c ; Shinichiro Nakajima^a ; ^c ; Eric Plitman^a ; ^b ; Yusuke Iwata^a ; ^b ; Alan Wilson^a ; ^b ; ^c ; Ariel Graff-Guerrero^a ; ^b ; ^c ; ^{ariel.graff@camh.ca" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Personality ; Dopamine ; D2/3R ; PET ; [11C]-raclopride
• 刊名：European Neuropsychopharmacology
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：26
• 期：4
• 页码：644-652
• 全文大小：933 K

文摘

While several studies have examined how particular personality traits are related to dopamine D_2/3 receptor (D_2/3R) availability in the striatum of humans, few studies have reported how multiple traits measured in the same persons are differentially related to D_2/3R availability in different striatal sub-regions. We examined how personality traits measured with the Karolinska Scales of Personality are related to striatal D_2/3R availability measured with [¹¹C]-raclopride in 30 healthy humans. Based on previous the literature, five personality traits were hypothesized to be most likely related to D_2/3R availability: impulsiveness, monotony avoidance, detachment, social desirability, and socialization. We found self-reported impulsiveness was negatively correlated with D_2/3R availability in the ventral striatum and globus pallidus. After controlling for age and gender, monotony avoidance was also negatively correlated with D_2/3R availability in the ventral striatum and globus pallidus. Socialization was positively correlated with D_2/3R availability in the ventral striatum and putamen. After controlling for age and gender, the relationship between socialization and D_2/3R availability in these regions survived correction for multiple comparisons (p-threshold=.003). Thus, within the same persons, different personality traits are differentially related to in vivo D_2/3R availability in different striatal sub-regions.