Nicotinic receptor blockade decreases fos immunoreactivity within orexin/hypocretin-expressing neurons of nicotine-exposed rats
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- 作者：Steven J. Simmonsa ; steven.simmons@temple.edu" class="auth_mail" title="E-mail the corresponding author ; Taylor A. Gentilea ; Lili Moa ; Fionya H. Trana ; Sisi Mab ; John W. Muschamp ; Ph.D.a ; john.muschamp@temple.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：CNS ; central nervous system ; DA ; dopamine ; ir ; immunoreactivity ; nAChR ; nicotinic acetylcholine receptor ; NAcc ; nucleus accumbens ; OxA ; orexin-A ; Ox1R ; orexin receptor subtype 1 ; Ox2R ; orexin receptor subtype 2 ; PBS ; phosphate-buffered saline ; VTA ; ventral tegmental area
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：1 November 2016
- 年：2016
- 卷：314
- 期：Complete
- 页码：226-233
- 全文大小：2806 K
文摘
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Mecamylamine induces somatic events and anxiety in rats given chronic nicotine.
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Nicotinic receptor blockade decreases Fos-immunoreactivity of orexin neurons.
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Orexin receptors should be assessed as targets for developing smoking cessation aides.