Metabolic pathways in the periphery and brain: Contribution to mental disorders?

详细信息    查看全文

• 作者：Andrzej Nagalski¹ ; Kamil Kozinski¹ ; Marta B. Wisniewska ; ¹ ; ^{m.wisniewska@uw.edu.pl" class="auth_mail" title="E-mail the corresponding author}
• 关键词：ACCORD-MIND ; Action to Control Cardiovascular Risk in Diabetes&mdash ; Memory in Diabetes ; BBB ; blood-brain barrier ; BD ; bipolar disorder ; BDNF ; brain-derived neurotrophic factor ; DISC1 ; disrupted in schizophrenia 1 ; GLUT ; glucose transporter ; GSK3 ; glycogen synthase kinase 3 ; GWAS ; genome-wide association study ; HPA ; hypothalamic-pituitary-adrenal ; IL ; interleukin ; INSR ; insulin receptor ; MAPK ; mitogen-activated protein kinase ; MD ; major depression ; MRI ; magnetic resonance imaging ; NHGRI-EBI ; Nat
• 刊名：International Journal of Biochemistry and Cell Biology
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：80
• 期：Complete
• 页码：19-30
• 全文大小：1942 K

文摘

The association between mental disorders and diabetes has a long history. Recent large-scale, well-controlled epidemiological studies confirmed a link between diabetes and psychiatric illnesses. The scope of this review is to summarize our current understanding of this relationship from a molecular perspective. We first discuss the potential contribution of diabetes-associated metabolic impairments to the etiology of mental conditions. Then, we focus on possible shared molecular risk factors and mechanisms. Simple comorbidity, shared susceptibility loci, and common pathophysiological processes in diabetes and mental illnesses have changed our traditional way of thinking about mental illness. We conclude that schizophrenia and affective disorders are not limited to an imbalance in dopaminergic and serotoninergic neurotransmission in the brain. They are also systemic disorders that can be considered, to some extent, as metabolic disorders.