- 作者：Benjamin J.W. Chow ; MD<sup>&lowast ; sup><sup> ; sup><sup>&dagger ; sup><sup> ; sup><sup>bchow@ottawaheart.ca" class="auth_mailsup> ; Sharmila Dorbala ; MD ; MPH<sup>&Dagger ; sup> ; Marcelo F. Di Carli ; MD<sup>&Dagger ; sup> ; Michael E. Merhige ; MD<sup>§ ; sup> ; Brent A. Williams ; PhD<sup>鈥?/sup> ; Emir Veledar ; PhD<sup>¶ ; sup> ; James K. Min ; MD<sup>#sup> ; Michael J. Pencina ; PhD<sup>&lowast ; &lowast ; sup> ; Yeung Yam ; BSc<sup>&lowast ; sup> ; Li Chen ; MSc<sup>&lowast ; sup><sup> ; sup><sup>&dagger ; &dagger ; sup> ; Sai Priya Anand ; BSc<sup>&lowast ; sup> ; Terrence D. Ruddy ; MD<sup>&lowast ; sup><sup> ; sup><sup>&dagger ; sup> ; Daniel S. Berman ; MD<sup>&Dagger ; &Dagger ; sup> ; Leslee J. Shaw ; PhD<sup>¶ ; sup> ; Rob S. Beanlands ; MD<sup>&lowast ; sup>
- 关键词：cardiac death ; obesity ; positron emission tomography ; prognosis
- 刊名：JACC: Cardiovascular Imaging
- 出版年：March, 2014
- 年：2014
- 卷：7
- 期：3
- 页码：278-287
- 全文大小：276 K
ss="h4">Objectives
This study sought to determine and compare the prognostic and incremental value of聽positron emission tomography (PET) in normal, overweight, and obese patients.ss="h4">Background
Cardiac rubidium 82 (Rb-82) PET is increasingly being used for myocardial perfusion imaging (MPI). A strength of PET is its accurate attenuation correction, thereby potentially improving its diagnostic accuracy in obese patients. The prognostic value of PET in obese patients has not been well studied.
ss="h4">Methods
A total of 7,061 patients who had undergone Rb-82 PET MPI were entered into a multicenter observational registry. All patients underwent pharmacologic Rb-82 PET and were followed for cardiac death and all-cause mortality. Based on body mass index (BMI), patients were categorized as normal (<25 kg/m<sup>2sup>), overweight (25 to 29.9 kg/m<sup>2sup>), or obese (鈮?0 kg/m<sup>2sup>). Using a 17-segment model and 5-point scoring system, the percentage of abnormal myocardium was calculated for stress and rest patients categorized as normal (0%), mild (0.1% to 9.9%), moderate (10% to 19.9%), and severe (鈮?0%).
ss="h4">Results
A total of 6,037 patients were followed for cardiac death (median: 2.2 years) and the mean BMI was 30.5 卤 7.4 kg/m<sup>2sup>. A total of 169 cardiac deaths were observed. PET MPI demonstrated independent and incremental prognostic value over BMI. Normal PET MPI conferred an excellent prognosis with very low annual cardiac death rates in normal (0.38%), overweight (0.43%), and obese (0.15%) patients. As well, both moderately and severe obese patients with a normal PET MPI had excellent prognosis (0.20% and 0.10%, respectively). The net reclassification improvement of PET was 0.46 (95% confidence interval [CI]: 0.31 to 0.61), and appeared similar in the moderately and severe obese patients which were 0.44 (95% CI: 0.12 to 0.76) and 0.63 (95% CI: 0.27 to 0.98), respectively.
ss="h4">Conclusions
Rb-82 PET has incremental prognostic value in all patients irrespective of BMI. In聽the obese population, where other modalities may have reduced diagnostic accuracy, cardiac PET聽appears to聽be a promising noninvasive modality with prognostic value.