Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8+ T Cell Exhaustion
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- 作者：Bertram Bengsch1 ; 2 ; Andy L. Johnson1 ; 2 ; Makoto Kurachi1 ; 2 ; Pamela M. Odorizzi1 ; 2 ; Kristen E. Pauken1 ; 2 ; John Attanasio1 ; 2 ; Erietta Stelekati1 ; 2 ; Laura M. McLane1 ; 2 ; Michael A. Paley1 ; 2 ; Greg M. Delgoffe3 ; E. John Wherry1 ; 2 ; wherry@mail.med.upenn.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Immunity
- 出版年：2016
- 出版时间：16 August 2016
- 年：2016
- 卷：45
- 期：2
- 页码：358-373
- 全文大小：3063 K
文摘
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Early exhausted T cells exhibit repressed glycolytic and mitochondrial metabolism
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Metabolic skewing occurred despite mTOR-driven upregulation of anabolic pathways
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PD-1 regulated bioenergetic insufficiencies early and late in infection
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PGC-1α overexpression improved metabolism and T cell function