Midkine is up-regulated in both cancerous and inflamed bowel, reflecting lymph node metastasis in colorectal cancer and clinical activity of ulcerative colitis

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• 作者：Malgorzata Krzystek-Korpacka^a ; ^{malgorzata.krzystek-korpacka@umed.wroc.pl} ; ^{gosia.krzystek@gmail.com} ; Sabina Gorska^b ; Dorota Diakowska^c ; Bartosz Kapturkiewicz^d ; Magdalena Podkowik^e ; Andrzej Gamian^a ; ^f ; Iwona Bednarz-Misa^a
• 关键词：Midkine ; Colorectal cancer ; Inflammatory bowel disease ; Ulcerative colitis ; Crohn&rsquo ; s disease ; Surgical stress
• 刊名：Cytokine
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：89
• 期：Complete
• 页码：68-75
• 全文大小：519 K
• 卷排序：89

文摘

Midkine overexpression in colon and leukocytes accompanies regional metastasis in CRC. Midkine is overexpressed in inflamed bowel only in ulcerative colitis. Midkine expression in tumor-adjacent tissue is upregulated and depends on CRC stage. Serum midkine drops directly after surgery but its levels are restored on 3rd day.