An immunocytochemical mapping of β-endorphin (1–27) in the cat diencephalon

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• 作者：R. Coveñ ; as ; M. de Leó ; n ; J. A. Narvá ; ez ; G. Tramu ; J. A. Aguirre ; S. Gonzá ; lez-Baró ; n
• 关键词：ransgenic mice ; corticosteroid receptor ; depression ; anxiety ; HPA system ; stress ; animal model
• 刊名：Neuropeptides
• 出版年：1996
• 出版时间：June 1996
• 年：1996
• 卷：30
• 期：3
• 页码：261-271
• 全文大小：5889 K

文摘

The distribution of β-endorphin (1–27) immunoreactive cell bodies and fibres was studied in the diencephalon of the cat using an indirect immunoperoxidase technique. In the thalamus, almost all the immunoreactive fibres were found in the midline region and in nuclei located near the midline, whereas in the hypothalamus fibres containing β-endorphin (1–27) were visualized extending by the whole structure. The hypothalamus showed a higher density of β-endorphin (1–27) immunoreactive fibres than the thalamus, as well as immunoreactive cell bodies, since in the thalamus no β-endorphin (1–27) immunoreactive neuron was located. The densest network of immunoreactive fibres was observed in the epithalamus (nucleus periventricularis anterior) and in the hypothalamic nuclei arcuatus, hypothalami ventromedialis, suprachiasmaticus, periventricularis hypothalami, hypothalamus dorsomedialis, area hypothalamica dorsalis, hypothalamus anterior, filiformis, hypothalamus posterior and regio praeoptica. In the hypothalamus, a high density of perikarya containing β-endorphin (1–27) was observed in the nucleus arcuatus and a low density in the nucleus hypothalami ventromedialis. The distribution of β-endorphin (1–27) immunoreactive fibres and perikarya is compared with the location of other neuropeptides in the cat diencephalon. Our findings reveal that b-endorphin (1–27) immunoreactive structures are widely distributed in the cat diencephalon, suggesting that the peptide might be involved in several physiological functions.