Reduced DNA double-strand break repair capacity and risk of squamous cell carcinoma of the head and neck—A case-control study
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- 作者：Zhensheng Liua ; b ; 1 ; Hongliang Liua ; b ; 1 ; Fengqin Gaoa ; b ; Kristina R. Dahlstromc ; Erich M. Sturgisc ; d ; Qingyi Weia ; b ; qingyi.wei@duke.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：DSBs ; DNA double-strand breaks ; ETOP ; etoposide ; SCCHN ; squamous cell carcinoma of the head and neck ; OR ; odds ratio ; CI ; confidence interval
- 刊名：DNA Repair
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：40
- 期：Complete
- 页码：18-26
- 全文大小：1634 K
文摘
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We used a method to detect the DNA double strand break repair capacity.
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We examined the DSBRC in 100 head and neck cancer patients and 124 controls.
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DNA double strand break repair capacity was significantly lower in cases than in controls.
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Decreased DSBRC may be associated with increased risk of head and neck cancer.