- 作者：Daniel M. Breitkopf ; MD ; breitkopf.daniel@mayo.edu ; Matthew R. Hopkins ; MD ; Shannon K. Laughlin-Tommaso ; MD ; Douglas J. Creedon ; MD ; PhD ; Abimbola O. Famuyide ; MBBS
- 关键词：Endometrial biopsy ; Hysteroscopy
- 刊名：Journal of Minimally Invasive Gynecology
- 出版年：2012
- 出版时间：July-August, 2012
- 年：2012
- 卷：19
- 期：4
- 页码：490-493
- 全文大小：186 K
Study Objective
To determine feasibility and efficacy of direct aspiration endometrial biopsy via the fluid channel of?a flexible diagnostic hysteroscope.Design
Retrospective review (Canadian Task Force classification II-3).
Setting
Abnormal uterine bleeding clinic in a tertiary care center.
Patients
All women who underwent direct aspiration endometrial biopsy from January 2007 through August 2011 via a flexible diagnostic hysteroscope because traditional office-based endometrial biopsy using a suction piston device was not technically possible.
Interventions
Diagnostic hysteroscopy followed by direct aspiration endometrial biopsy, accomplished by applying suction to the fluid channel of a 3.1-mm flexible diagnostic hysteroscope via a 10-mL syringe. The hysteroscope tip was agitated within the uterine cavity to obtain a tissue sample.
Measurements and Main Results
The median age of the 32 identified patients was 50 years; 18 women (56 % ) were nulliparous, and 10 (31 % ) were postmenopausal. Thirty-one patients underwent hysteroscopy/direct aspiration biopsy because of abnormal uterine bleeding or postmenopausal bleeding. The vaginoscopic approach was used in 19 patients (59 % ). Indications for direct aspiration endometrial biopsy included cervical stenosis, inability to pass the endometrial biopsy instrument into the uterine cavity, and patient intolerance of endometrial biopsy. Adequate endometrial samples were obtained in 28 patients (87.5 % ). In 3 of 4 patients in whom direct aspiration endometrial biopsy did not provide sufficient tissue, hysteroscopy revealed an atrophic-appearing endometrium. The direct aspiration endometrial biopsy diagnosis was confirmed in 5 of 7 patients who subsequently underwent dilation and curettage or hysterectomy.
Conclusion
Direct aspiration endometrial biopsy is a simple and effective endometrial sampling method when traditional office-based endometrial biopsy is not feasible. Further prospective studies including larger populations are needed to confirm these results.