Evaluation of the Tobacco Heating System 2.2 (THS2.2). Part 5: microRNA expression from a 90-day rat inhalation study indicates that exposure to THS2.2 aerosol causes reduced effects on lung tissue compared with cigarette smoke

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• 作者：Alain Sewer^a ; ^{alain.sewer@pmi.com} ; Ulrike Kogel^a ; Marja Talikka^a ; Ee Tsin Wong^b ; Florian Martin^a ; Yang Xiang^a ; Emmanuel Guedj^a ; Nikolai V. Ivanov^a ; Julia Hoeng^a ; Manuel C. Peitsch^a
• 关键词：Heat-not-burn ; Modified risk tobacco product ; Inhalation toxicology study ; microRNA expression ; Inflammation-related microRNAs
• 刊名：Regulatory Toxicology and Pharmacology
• 出版年：2016
• 出版时间：30 November 2016
• 年：2016
• 卷：81
• 期：supp_S2
• 页码：S82-S92
• 全文大小：2256 K
• 卷排序：81

文摘

MicroRNA (miRNA) profile analysis complements the systems toxicology assessment. Lungs of rats exposed to cigarette smoke (CS) or THS2.2 aerosol were examined. Global miRNA downregulation was observed after 90-day CS exposure. Inflammation-related miR-146a/146b/182 were strongly regulated upon CS exposure. miRNAs from the DLK1-DIO3 domain were down/up-regulated upon CS/THS2.2 exposure.