文摘
Four types of commercial enoxaparins were analyzed by integrated LC–MS and NMR analysis. Heparinase treatment was used before bottom-up analysis and disaccharide analysis. Intact chain, oligosaccharide, and disaccharide analyses relied on LC–MS. Monosaccharide compositional analysis relied on top-down NMR analysis. Generic enoxaparins and innovator product are similar, differences are observed due to parent heparin and process conditions.