BCL-2: A New Therapeutic Target in Estrogen Receptor-Positive Breast Cancer?

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• 作者：Lesley-Ann Martin ; Mitch Dowsett
• 刊名：Cancer Cell
• 出版年：2013
• 出版时间：8 July, 2013
• 年：2013
• 卷：24
• 期：1
• 页码：7-9
• 全文大小：397 K

文摘

Prosurvival protein BCL-2 is overexpressed in estrogen receptor positive (ER⁺) breast cancer. In this issue of m>Cancer Cellm>, Vaillant and colleagues demonstrate that targeting BCL-2 with BH3 mimetics improves the response of xenografts from primary ER⁺ breast tumors to endocrine therapy and reduces tamoxifen-induced endometrial hyperplasia, a strategy with potential clinical applicability.