Improved cytotoxicity and preserved level of cell death induced in colon cancer cells by doxorubicin after its conjugation with iron-oxide magnetic nanoparticles
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- 作者：Ewa Augustina ; ewa.augustin@pg.gda.pl" class="auth_mail" title="E-mail the corresponding author ; Bartłomiej Czubeka ; vbart4@wp.pl" class="auth_mail" title="E-mail the corresponding author ; Anna M. Nowickab ; anowicka@chem.uw.edu.pl" class="auth_mail" title="E-mail the corresponding author ; Agata Kowalczykb ; akowalczyk@chem.uw.edu.pl" class="auth_mail" title="E-mail the corresponding author ; Zbigniew Stojekb ; stojek@chem.uw.edu.pl" class="auth_mail" title="E-mail the corresponding author ; Zofia Mazerskaa ; zofia.mazerska@pg.gda.pl" class="auth_mail" title="E-mail the corresponding author
- 关键词：CV ; cyclic voltammetry ; Dox-NPs ; magnetic (iron-oxide) nanoparticle and doxorubicin conjugates ; DTX ; docetaxel ; HT29 cells ; human adenocarcinoma colon cell line ; Np-C6 ; magnetic nanoparticle functionalized by adipoyl linker ; SEM ; scanning electron microscopy ; TGA ; thermogravimetric analysis
- 刊名：Toxicology in Vitro
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：33
- 期：Complete
- 页码：45-53
- 全文大小：2381 K
文摘
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Iron-oxide doxorubicin nanoparticles (Dox-Nps) were applied to improve anticancer drug delivery.
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Cytotoxicity of Dox-Nps was two/three times higher than free Dox, whereas Nps alone were not cytotoxic against HT29 cells.
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Dox-Nps were observed to penetrate cancer cells with higher efficacy than free Dox.
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The treatment of HT-29 cells with Dox-Nps and Dox at IC50 resulted in G2/M arrest followed by apoptosis and necrosis.