Using solution X-ray scattering to determine the high-resolution structure and morphology of PEGylated liposomal doxorubicin nanodrugs
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- 作者：Y. Schilta ; c ; T. Bermanb ; c ; X. Weib ; 1 ; Y. Barenholzb ; c ; chezyb@gmail.com" class="auth_mail" title="E-mail the corresponding author ; U. Raviva ; c ; uri.raviv@mail.huji.ac.il" class="auth_mail" title="E-mail the corresponding author
- 关键词：EPR ; Enhanced permeability and retention ; PLD ; PEGylated liposomal doxorubicin ; FDA ; Food and Drug Administration ; EMA ; European Medicines Agency
- 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：1860
- 期：1
- 页码：108-119
- 全文大小：2029 K
文摘
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We studied PEGylated nanoliposomes before and after remote loading with doxorubicin.
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Solution x-ray scattering data were analyzed using our advanced analysis software.
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The high-resolution structures of Doxil®, its generics, and LC100 were determined.
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Doxil® and its generics are structurally similar within the experimental error.
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No drug-nanocrystals formed when ammonium methanesulfonate was used for remote loading.