Nitration of indoxyl sulfate facilitates its cytotoxicity in human renal proximal tubular cells via expression of heme oxygenase-1
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- 作者：Yu Ishimaa ; b ; Toru Narisokoa ; Ulrich Kragh-Hansenc ; Shunsuke Kotanid ; Makoto Nakajimad ; Masaki Otagirie ; f ; Toru Maruyamaa ; b ; tomaru@gpo.kumamoto-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Indoxyl sulfate ; Peroxynitrite ; Nitration ; Reactive oxygen species ; Heme oxygenase-1 ; NADPH oxidase
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2015
- 出版时间：25 September 2015
- 年：2015
- 卷：465
- 期：3
- 页码：481-487
- 全文大小：1438 K
文摘
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Indoxyl sulfate (IS) is most popular uremic toxin.
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IS is nitrated by peroxynitrite.
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The cytotoxicity of Nitrated-IS is several-fold higher than that of IS.
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Nitrated-IS is induced reactive oxygen species via heme oxygenase-1.