Assessment of the eye irritation potential of chemicals: A comparison study between two test methods based on human 3D hemi-cornea models
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- 作者：R. Tandona ; M. Bartoka ; dr.melinda.bartok@gmail.com" class="auth_mail" title="E-mail the corresponding author ; M. Zorn-Kruppab ; J.M. Brandnerb ; D. Gabela ; M. Engelkea
- 关键词：Human 3D hemi-cornea model ; Relative MTT-depth of injury ; Globally harmonized system of classification and labeling of chemicals ; The Draize eye irritation test
- 刊名：Toxicology in Vitro
- 出版年：2015
- 出版时间：25 December 2015
- 年：2015
- 卷：30
- 期：1
- 页码：561-568
- 全文大小：1129 K
文摘
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The prediction capacity of two in vitro hemi-cornea test methods was compared.
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With 60 min exposure both test methods can discriminate GHS 2 and GHS 1 chemicals.
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Both test methods can be a potential replacement of the in vivo Draize eye test.