Differential effects of nitric oxide synthase inhibitor, 7-nitroindazole, on discriminative stimulus and somatic effects of naloxone in morphine-dependent rats

详细信息    查看全文

• 作者：Medvedev ; Ivan O. ; Dravolina ; Olga A. ; Bespalov ; Anton Y.
• 关键词：Naloxone ; Morphine withdrawal ; Nitric oxide (NO) synthase inhibitor ; Drug discrimination ; Y-maze ; (Rat)
• 刊名：European Journal of Pharmacology
• 出版年：1999
• 出版时间：July 21, 1999
• 年：1999
• 卷：377
• 期：2-3
• 页码：183-186
• 全文大小：61.3 K

文摘

Our previous report suggested that antagonists acting at NMDA receptors attenuate discriminative stimulus effects of naloxone in morphine dependent rats. Nitric oxide (NO) is a putative second messenger which mediates NMDA receptor activation. The present study evaluated behavioral effects of NO synthase inhibitor, 7-nitroindazole in morphine-dependent rats trained to discriminate 0.1 mg/kg naloxone from saline. 7-Nitroindazole did not significantly affect naloxone's discriminative stimulus effects but decreased naloxone-induced weight loss and abolished expression of several withdrawal signs — diarrhea, scream on touch, tremor and ‘wet dog'-like shaking suggesting different mechanisms for subjective and somatic components of opioid withdrawal.