Investigating the structural impact of S311C mutation in DRD2 receptor by molecular dynamics & docking studies
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- 作者：Avijit Podder ; Deeksha Pandey ; N. Latha ; lata@bic-svc.ac.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：Dopamine receptor D2 (DRD2) ; S311C mutation ; Molecular docking ; Molecular dynamics (MD) simulations ; Residue interactions network (RIN)
- 刊名：Biochimie
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：123
- 期：Complete
- 页码：52-64
- 全文大小：4069 K
文摘
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3-D structure modeling of DRD2 wild type and mutant S311C.
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Docking studies of DRD2 (WT and mutant) with natural agonist Dopamine.
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Molecular dynamics (MD) simulations of modeled structures and docked complexes.
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Protein–protein docking of dopamine bound DRD2 (WT and mutant) with Gαi/o and NEB2.