Plasma sulfur amino acids and stearoyl-CoA desaturase activity in two caucasian populations

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• 作者：K.J. Vinknes ; J.M. Dekker ; C.A. Drevon ; H. Refsum ; E. Nurk ; G. Nijpels ; C.D.A. Stehouwer ; T. Teerlink ; G.S. Tell ; O. Nyg氓rd ; S.E. Vollset ; P.M. Uel ; A.K. Elshorbagy
• 关键词：Cysteine ; Sulfur amino acids ; Stearoyl-CoA desaturase ; Fatty acid profile
• 刊名：Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)
• 出版年：October, 2013
• 年：2013
• 卷：89
• 期：5
• 页码：297-303
• 全文大小：433 K

文摘

In rats, dietary restriction of the cysteine precursor methionine suppresses hepatic stearoyl-CoA desaturase (SCD)-1 expression and activity, whereas cysteine supplementation reverses these effects. In 2 independent cohorts: Hordaland Health Study (HUSK; m>Nm>=2021, aged 71-74 y), Norway, and Hoorn study (m>Nm>=686, aged 50-87 y), Netherlands, we examined the cross-sectional associations of plasma sulfur-containing compounds (SCC; methionine, S-adenosylmethionine, S-adenosylhomocysteine, homocysteine, cystathionine, total cysteine (tCys), glutathione and cysteinylglycine) with SCD-16 index (16:1n-7/16:0), estimated from fatty acid profiles of total plasma or serum lipids. Only tCys was consistently associated with SCD-16 index after adjustments for sex and age (HUSK: partial m>rm>=0.14; Hoorn: partial m>rm>=0.11, m>Pm><0.001 for both), and after further adjustments for other SCC, body fat, diet, exercise and plasma lipids (HUSK: partial m>rm>=0.07, m>Pm>=0.004; Hoorn: partial m>rm>=0.12, m>Pm>=0.013). Together with animal data showing an effect of dietary cysteine on SCD1, our results suggest a role for cysteine in SCD1 regulation in humans.