Poly-arginine conjugated triarylmethyl radical as intracellular spin label

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• 作者：Benoit Driesschaert^a ; ^b ; Andrey A. Bobko^a ; ^b ; Timothy D. Eubank^a ; ^c ; Alexandre Samouilov^d ; Valery V. Khramtsov^a ; ^b ; Jay L. Zweier^d ; ^{jay.zweier@osumc.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：EPR ; TAM ; Poly-arginine ; Radical ; Cyclic voltammetry
• 刊名：Bioorganic & Medicinal Chemistry Letters
• 出版年：2016
• 出版时间：1 April 2016
• 年：2016
• 卷：26
• 期：7
• 页码：1742-1744
• 全文大小：489 K

文摘

Stable triarylmethyl radicals are ideal spin labels used for biomedical electron paramagnetic resonance applications. Previously reported structures exhibit polar charged functions for water solubilization preventing them from crossing the cell membrane. We report the synthesis of a triarylmethyl radical conjugated to poly-arginine peptide allowing intracellular delivery of the paramagnetic label.