The early stage of experimentally induced secondary HAE in 157 rats was studied by ultrasonography. The features of all lesions were recorded, and compared with pathological results.
The sensitivity and specificity of ultrasonography was 93.5%, (95% confidence interval: 76%–98%) and 83.3% (95% confidence interval: 65%–93%), respectively. The typical features of early HAE in ultrasonography presented as solid hyperechoic masses and mixed lesions. Blood flow was detected in only three lesions by Color Doppler Flow Imaging. Calcifications were detected in 17 lesions which were larger than 8 mm. Lesions presented as single or multiple cystic structure, surrounded with the proliferation of small blood vessels, epithelioid cells, macrophages, fibroblasts, lymphocytes and fibrous tissue in the liver.
Our data suggested that ultrasonography could be used as a screening method for early Echinococcusmultilocularis lesions in the animal model. Calcification could be occurred in those lesions with fast growth of the parasite in short cycle. The typical features of early HAE presented as hyper-echoic with small size in ultrasonography.