- 作者：Nesreen A.A. Shehata ; nesoomar@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Premenstrual syndrome ; Drospirenone ; Oral contraceptive pills ; Calcium supplements ; PMS treatment
- 刊名：European Journal of Obstetrics & Gynecology and Reproductive Biology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：198
- 期：Complete
- 页码：100-104
- 全文大小：323 K
Study Design
This was a double-blind, randomized placebo controlled trial conducted in Beni-Suef University Hospital. Premenstrual syndrome (PMS) was prospectively diagnosed using the Daily Record of Severity of Problems (DRSP). In total, 210 women with mild to moderate PMS were randomly divided into three equal groups. Group 1 received COC daily for 21 days starting on the third day of menstruation and a daily oral placebo similar to calcium and vitamin D. Group 2 received calcium 400 mg + vitamin D 400 IU once daily and an oral placebo similar to COC for 21 days starting on the third day of menstruation. Group 3 received a daily placebo similar to calcium and vitamin D in addition to an oral placebo similar to COC for 21 days starting on the third day of menstruation. Treatment was continued for 3 months.
Results
The proportion of women with improved PMS decreased progressively from the COC group to the calcium group and the placebo group (81%, 62.3% and 16.3%, respectively; p < 0.001). Similarly, mean DRSP scores 5 days before menstruation decreased progressively from the COC group, the calcium group and the placebo group (45.51 ± 16.97, 55 ± 15.71 and 74.98 ± 19.12, respectively; p < 0.001).
Conclusion
Both COC and calcium supplements improved DRSP scores in women with mild to moderate PMS, but the improvement was more evident with COC.