Antisense Transcripts Delimit Exonucleolytic Activity of the Mitochondrial 3′ Processome to Generate Guide RNAs
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- 作者：Takuma Suematsu1 ; 5 ; Liye Zhang2 ; 5 ; Inna Aphasizheva1 ; Stefano Monti2 ; Lan Huang3 ; Qi Wang4 ; Catherine E. Costello4 ; Ruslan Aphasizhev1 ; 4 ; ruslana@bu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：trypanosoma ; mitochondria ; guide RNA ; RNA editing ; RNA decay ; TUTase ; exonuclease
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：4 February 2016
- 年：2016
- 卷：61
- 期：3
- 页码：364-378
- 全文大小：4031 K
文摘
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Trypanosome mitochondrial gRNAs are produced from the 5′ region of a long precursor
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RET1 TUTase and DSS1 exonuclease function as subunits of the 3′ processome (MPsome)
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RET1-catalyzed uridylation induces 3′-5′ degradation of gRNA precursor
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Antisense transcripts control exonucleolytic processing to define mature 3′ end