RNA Degradation in Yeast and Human Mitochondria

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• 作者：Roman J. Szczesny ; Lukasz S. Borowski ; Michal Malecki ; Magdalena A. Wojcik ; Piotr P. Stepien ; Pawel Golik
• 关键词：mitochondrial degradosome ; RNA degradation ; Suv3 helicase (SUPV3L1 hSuv3p ; hSuv3 ; Suv3p) ; Dss1 ribonuclease ; polynucleotide phosphorylase (PNPase)
• 刊名：Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
• 出版年：2012
• 出版时间：September-October, 2012
• 年：2012
• 卷：1819
• 期：9-10
• 页码：1027-1034
• 全文大小：307 K

文摘

Expression of mitochondrially encoded genes must be finely tuned according to the cell's requirements. Since yeast and human mitochondria have limited possibilities to regulate gene expression by altering the transcription initiation rate, posttranscriptional processes, including RNA degradation, are of great importance. In both organisms mitochondrial RNA degradation seems to be mostly depending on the RNA helicase Suv3. Yeast Suv3 functions in cooperation with Dss1 ribonuclease by forming a two-subunit complex called the mitochondrial degradosome. The human ortholog of Suv3 (hSuv3, hSuv3p, SUPV3L1) is also indispensable for mitochondrial RNA decay but its ribonucleolytic partner has so far escaped identification. In this review we summarize the current knowledge about RNA degradation in human and yeast mitochondria. This article is part of a Special Issue entitled: Mitochondrial Gene Expression.