The neural diathesis-stress model of schizophrenia revisited: An update on recent findings considering illness stage and neurobiological and methodological complexities

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• 作者：Marita Pruessner^a ; ¹ ; ^{marita.pruessner@mcgill.ca} ; Alexis E. Cullen^b ; Monica Aas^c ; Elaine F. Walker^d
• 关键词：2-DG ; 2-deoxy-d-glucose ; ACTH ; adrenocorticotropin releasing hormone ; AUC ; area under the curve ; ALT ; autoregressive latent trajectory ; BDNF ; brain-derived neurotrophic factor ; CHR ; clinical high-risk ; CAARMS ; comprehensive assessment of at-risk mental states ; CRH ; corticotrophin releasing hormone ; CAR ; cortisol awakening response ; DST ; dexamethasone suppression test ; DA ; dopamine ; ESM ; experience sampling method ; FEP ; first episode of psychosis ; fMRI ; functional magnetic resonance imaging ; GHR
• 刊名：Neuroscience & Biobehavioral Reviews
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：73
• 期：Complete
• 页码：191-218
• 全文大小：2969 K
• 卷排序：73

文摘

Distinct patterns of HPA axis dysregulation in psychosis are observed for basal, stress-induced and awakening cortisol HPA axis alterations in clinical high risk populations resemble those observed in established psychosis, but are less consistent Confounding factors and challenges in the measurement of stress, cortisol, and symptomatic outcome affect interpretation of results Genetic, epigenetic, neurodevelopmental and environmental factors may modulate the effects of HPA axis abnormalities on psychosis progression HPA axis activity in psychosis appears to be associated with altered neurotransmitter activity, inflammatory processes and brain structure