A hepatic metabolomics-based diagnostic approach to assess lethal toxicity of dithiocarbamate fungicide polycarbamate in three marine fish species

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• 作者：Takeshi Hano ; ^{hntks@affrc.go.jp} ; ; Nobuyuki Ohkubo ^{nobuyuki@affrc.go.jp} ; Kazuhiko Mochida ^{kmochida@affrc.go.jp}
• 关键词：PC ; polycarbamate ; GSH ; reduced glutathione ; DTCs ; dithiocarbamate fungicides
• 刊名：Ecotoxicology and Environmental Safety
• 出版年：2017
• 出版时间：April 2017
• 年：2017
• 卷：138
• 期：Complete
• 页码：64-70
• 全文大小：678 K
• 卷排序：138

文摘

Polycarbamate (PC) exhibited lethal toxicity in three marine fish species. PC caused perturbation of hepatic metabolite profile. Elevation of reduced glutathione (GSH) was associated with lethal toxicity. Use of GSH cut-off values can assess the life-threatening condition of fish.