Targeting NF-κB RelA/p65 phosphorylation overcomes RITA resistance
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- 作者：Yiwen Bua ; Guoshuai Caib ; Yi Shena ; Chenfei Huanga ; Xi Zengc ; Yu Caoa ; Chuan Caid ; Yuhong Wangd ; Dan Huangd ; Duan-Fang Liaod ; dfliao66@aliyun.com" class="auth_mail" title="E-mail the corresponding author ; Deliang Caoa ; d ; dcao@siumed.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：NF-κB RelA/p65 ; ABCC6 ; RITA ; Chemoresistance
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：28 December 2016
- 年：2016
- 卷：383
- 期：2
- 页码：261-271
- 全文大小：4167 K
文摘
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NF-κB pathway is involved in acquired resistance of RITA.
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NF-κB dually regulates RITA chemosensitivity through distinct phosphorylation on RelA/p65.
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ABCC6 is a key target of RelA/p65 mediated RITA resistance.