Pluripotency without Proliferation

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• 作者：Xiaodong Shu¹ ; Duanqing Pei¹ ; ^{pei_duanqing@gibh.ac.cn" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Cell
• 出版年：2016
• 出版时间：11 February 2016
• 年：2016
• 卷：164
• 期：4
• 页码：595-597
• 全文大小：343 K

文摘

Mouse embryonic stem cells (mESCs) are capable of unlimited proliferation without losing pluripotency. Scognamiglio et al. now reveal that Myc depletion shifts mESCs into a dormant state reminiscent of embryonic diapause in which pluripotency remains fully preserved, thus decoupling pluripotency from proliferative programs.