MicroRNAs in somatic cell reprogramming

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• 作者：Xichen Bao ; Xihua Zhu ; Baojian Liao ; Christina Benda ; Qiang Zhuang ; Duanqing Pei ; Baoming Qin ^{qin_baoming@gibh.ac.cn} ; Miguel A Esteban ^{esteban@gibh.org maestebanb@gmail.com}
• 刊名：Current Opinion in Cell Biology
• 出版年：2013
• 出版时间：April, 2013
• 年：2013
• 卷：25
• 期：2
• 页码：208-214
• 全文大小：609 K

文摘

The generation of induced pluripotent stem (iPS) cells by exogenous transcription factors involves a comprehensive rearrangement of cellular functions, including the microRNA profile. The resulting cell lines are similar to embryonic stem (ES) cells and have therefore raised much interest for in vitro studies and the perspective of clinical application. Yet, microRNAs are not mere listeners of the reprogramming orchestra but play an active role in the process. In consequence, overexpression or suppression of individual microRNAs has profound effects in colony formation efficiency, and in combination they can produce iPS cells without added transcription factors. Moreover, variations in microRNA expression of iPS/ES cells can predict their differentiation potential and may have consequences at other levels. Altogether, these findings highlight the relevance of pursuing further these studies.