Infection of HepG2 cells with recombinant adenovirus encoding the HCV core protein induces p21^WAF1 down-regulation – effect of transforming growth factor β

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• 作者：Dubourdeau ; Marc ; Miyamura ; Tatsuo ; Matsuura ; Yoshiharu ; Alric ; Laurent ; Pipy ; Bernard ; Rousseau ; Denis
• 关键词：Viral protein ; p53 effector ; Cytokine ; HCV ; hepatitis C virus ; HCC ; hepatocellular carcinoma ; TGFβ ; transforming growth factor beta type 1 ; ONPG ; ortho-nitrophenyl-galactopyranoside
• 刊名：Journal of Hepatology
• 出版年：2002
• 出版时间：October, 2002
• 年：2002
• 卷：37
• 期：4
• 页码：486-492
• 全文大小：260 K

文摘

Background/Aims: Chronic infection with hepatitis C virus leads to liver cirrhosis and hepatocellular carcinoma. Hepatocellular carcinoma is sometimes associated with p53 dysfunction and decreased p21^WAF1 expression. The p21^WAF1 gene is a major target of p53, and p21^WAF1 protein regulates the activities of cyclin/CDK complexes involved in cell cycle control and tumor formation. Because core protein has oncogenic properties, we investigated the expression of p21^WAF1 following core expression.