Neuroprotective effects of pyrroloquinoline quinone against rotenone injury in primary cultured midbrain neurons and in a rat model of Parkinson's disease
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- 作者：Qi Zhanga ; 1 ; Shuhua Chena ; 1 ; Shu Yua ; Jiaojiao Qina ; Jingjing Zhanga ; Qiong Chenga ; Kaifu Keb ; Fei Dinga ; dingfei@ntu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pyrroloquinoline quinone (PQQ) ; Rotenone ; Neuroprotection ; Reactive oxygen species (ROS) ; Mitochondrial function ; Parkinson's disease (PD)
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：108
- 期：Complete
- 页码：238-251
- 全文大小：7009 K
文摘
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PQQ ameliorated rotenone-induced neuronal damage both in vitro and in vivo.
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PQQ reduced oxidative stress and improved mitochondrial functions in PD models.
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PQQ regulated microtubule depolymerization in rotenone injured neurons.
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Neuroprotection of PQQ might be mediated by modulation of Ndufs1 and Ndufs4.