Glutamatergic Neurotransmission Links Sensitivity to Volatile Anesthetics with Mitochondrial Function
详细信息 查看全文
- 作者：Pavel I. Zimin1 ; 3 ; pavel.zimin@seattlechildrens.org" class="auth_mail" title="E-mail the corresponding author ; Christian B. Woods1 ; 3 ; Albert Quintana1 ; 2 ; 5 ; Jan-Marino Ramirez2 ; Philip G. Morgan1 ; 4 ; Margaret M. Sedensky1 ; 4
- 刊名：Current Biology
- 出版年：2016
- 出版时间：22 August 2016
- 年：2016
- 卷：26
- 期：16
- 页码：2194-2201
- 全文大小：1832 K
文摘
- •
VGLUT2-specific loss of NDUFS4 causes whole-animal anesthetic hypersensitivity
- •
Isoflurane depresses hippocampal sEPSC frequencies selectively in Ndufs4(KO) mice
- •
sIPSCs are not affected by NDUFS4 loss
- •
The Ndufs4 mutation selectively affects presynaptic function in excitatory neurons