Activation of type 5 metabotropic glutamate receptor promotes the proliferation of rat retinal progenitor cell via activation of the PI-3-K and MAPK signaling pathways
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- 作者：Z. Zhang<sup>bsup><sup> ; sup><sup>&dagger ; sup> ; F. Hu<sup>asup><sup> ; sup><sup>csup><sup> ; sup><sup>&dagger ; sup> ; Y. Liu<sup>bsup> ; B. Ma<sup>asup> ; X. Chen<sup>bsup> ; K. Zhu<sup>bsup> ; Y. Shi<sup>asup> ; T. Wei<sup>asup> ; Y. Xing<sup>asup> ; Y. Gao<sup>bsup> ; H. Lu<sup>bsup> ; Y. Liu<sup>bsup><sup> ; sup><sup>liuy5599@mail.xjtu.edu.cn" class="auth_mail" title="E-mail the corresponding authorsup> ; Q. Kang<sup>asup><sup> ; sup><sup>kangqy@mail.xjtu.edu.cn" class="auth_mail" title="E-mail the corresponding authorsup>
- 关键词：AKT ; protein kinase B ; AMD ; age-related macular degeneration ; bFGF ; basic fibroblast growth factor ; BrdU ; 5-Bromo-2-deoxyUridine ; DHPG ; (S)-3 ; 5-dihydroxyphenylglycine hydrate ; DMEM/F12 ; Dulbecco&rsquo ; s Modified Eagle&rsquo ; s Medium and Hams F12 ; EGF ; epidermal growth factor ; ERKs ; extracellular signal-regulated protein kinases ; ES ; embryonic stem cells ; FACS ; fluorescence activated cell sorting ; MAPKs ; mitogen-activated protein kinases ; mGluRs ; metabotropic glutamate receptors ; MTEP ; 6-methyl-2
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：13 May 2016
- 年：2016
- 卷：322
- 期：Complete
- 页码：138-151
- 全文大小：3018 K
文摘
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Our research illuminates the relationship between mGluR5 and RPCs.
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mGluR5 promotes the proliferation of RPCs and enhances the expression of Cyclin D1.
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mGluR5 promotes the proliferation of RPCs via activation of the PI-3-K and MAPK signaling pathways.